By Lukas VainoriusPAINS are chemical compounds that often yield false positives in HTS. In fact, it is estimated that a typical academic screening library will contain roughly 5-12% of PAINS (2). There are approximately 400 structural classes of PAINS, with more than half of them falling under 16 easily identifiable groups (2). |NC State
By Lukas VainoriusThe National Center for Advancing Translational Sciences (NCATS), part of the
NIH, was established in 2011 to address a critical gap in bringing biomedical research
advances to patients by establishing a research program and developing a workforce
focused on these larger issues in improving health (Haynes et al., 2020). |NC State
By Lukas VainoriusThe SmartChip real-time PCR system is a great example of a novel high throughput technology, specifically in the realm of high throughput quantitative PCR (HT-qPCR). While standard quantitative PCR or digital PCR are widely used microbiological techniques, they are not high throughput because researchers are limited to screening for a specific amplicon |NC State
By Lukas VainoriusWith the population increasing, sustainability is at the forefront of the priority list for this generation’s scientific advances. Metabolic engineering has used yeast to provide meat alternatives, create biodegradable plastic, and synthesize opioids. |HTD
By Lukas VainoriusThe development of high-throughput technology revolutionized the field of drug discovery by allowing researchers to screen thousands of potential drug compounds in one day using a miniature assay format and automation.